Table 3. Univariate and multivariate analyses in two cohorts.

Variables	Discovery cohort						Validation cohort
	Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
	HR (95% CI)	P		HR (95% CI)	P		HR (95% CI)	P		HR (95% CI)	P
IS-mod, modified Immunoscore; HR, hazard ratio; 95% CI, 95% confidence interval.
Age	1.03 (1.01−1.06)	0.004		1.03 (1.01−1.05)	0.021		1.01 (0.98−1.04)	0.631
Sex
Male	1						1
Female	1.02 (0.62−1.68)	0.947					1.37 (0.59−3.17)	0.468
Stage
I	1			1
II	3.96 (0.52−30.1)	0.184		3.87 (0.51−29.5)	0.191		1			1
III	14.8 (2.04−107)	0.008		11.5 (1.59−83.8)	0.016		4.85 (1.64−14.4)	0.004		3.30 (1.01−9.17)	0.049
Location
Cecum ascending	1						1
Descending	0.43 (0.15−1.22)	0.113					0 (0−Inf)	0.997
Sigmoid	0.81 (0.48−1.37)	0.429					0.69 (0.26−1.85)	0.466
Transverse	0.54 (0.13−2.25)	0.379					0.68 (0.23−1.97)	0.477
IS-mod
Low	1			1			1			1
High	0.28 (0.16−0.49)	<0.001		0.36 (0.20−0.63)	<0.001		0.11 (0.02−0.46)	0.003		0.15 (0.03−0.67)	0.013