Table S1. Univariate and multivariate Cox regression analysis of variables associated with overall survival.
| Variables | Univariate analysis | Multivariate analysis | |||
| HR (95% CI) | P | HR (95% CI) | P | ||
| BCLC, Barcelona Clinic Liver Cancer; NEP, neoantigen expression probability; HR, hazard ratio; 95% CI, 95% confidence interval. | |||||
| Gender (female vs. male) | 0.035 (0.000−2.558) | 0.126 | − | − | |
| Age (>55vs. ≤55 years) | 0.903 (0.404−2.017) | 0.803 | − | − | |
| TNM stage (III+IV vs. I+II) | 2.425 (1.082−5.433) | 0.031 | 0.998 (0.232−4.295) | 0.998 | |
| BCLC stage (B+C vs. A) | 2.787 (1.239−6.269) | 0.013 | 1.965 (0.447−8.642) | 0.371 | |
| Tumor envelope (with vs. without) | 0.422 (0.141−1.259) | 0.122 | − | − | |
| Tumor thrombi (positive vs. negative) | 10.738 (2.477−46.545) | 0.002 | 7.943 (1.519−41.522) | 0.014 | |
| Microsatellite lesion (positive vs. negative) | 2.488 (1.008−6.143) | 0.048 | 0.796 (0.226−2.800) | 0.722 | |
| Alcohol (drinker vs. nondrinker) | 0.909 (0.337−2.453) | 0.851 | − | − | |
| Neoantigen load (high vs. low) | 0.278 (0.124−0.624) | 0.002 | 0.399 (0.054−2.932) | 0.367 | |
| Somatic mutation load (high vs. Low) | 0.386 (0.171−0.871) | 0.022 | 1.587 (0.219−11.477) | 0.647 | |
| Neoantigen expression propability (NEP-H vs. NEP-L) | 4.918 (1.462−16.544) | 0.010 | 2.831 (0.675−11.875) | 0.155 | |