Table 19.
Recommended surveillance protocols for common Lynch syndrome-associated tumors
| Site | Test method | Age at the start of testing | Test interval | Comments | References |
|---|---|---|---|---|---|
| Colorectum | Colonoscopy | 20–25 years | 1–2 years | [13, 126, 235–238] | |
| Uterus, ovary | Transvaginal US, endometrial biopsy | 30–35 years | 1 year | [13, 126, 235–238] | |
| (or cytology) (CA-125) | |||||
| Stomach, duodenum | HP infection | 30–35 years | Sterilization if HP infection is present | [13, 126, 235–237] | |
| Upper gastrointestinal endoscopy | 30–35 years | 1–3 years | Consider in populations at high risk of gastric cancer or with a family history of gastric or duodenal cancer | [13, 126, 235–237] | |
| Urinary tract | Urinalysis (or urine cytology) | 30–35 years | 1 year | Consider in cases where MSH2 variants or a Family history of urothelial carcinoma are present | [13, 235–238] |