Table 3.
NAFLD activity score (NAS)
| Group | Diet | Mice/number | Steatosis | Inflammation | Ballooning | Total NAS | NASH | |
|---|---|---|---|---|---|---|---|---|
| Micro/ macro (0–3) | Lobular (0–3) | Portal (0–3) | Hepatocyte (0–2) | Score (0–8) | ||||
| Cc1+/+ | RD | >3 | 0 | ≤ 1 | 0 | 0 | ≤ 1 | No |
| Cc1+/+ | HF | >3 | 2 | ≤ 2 | 0 | 0 | ≤ 4 | No |
| L-CC1 | RD | >4 | 0 | ≤ 1 | 0 | 0 | ≤ 1 | No |
| L-CC1 | HF | >3 | 2 | ≤ 2 | 0 | 0 | ≤ 4 | No |
| Cc1−/− | RD | >3 | ≤ 2 | 1 | ≤ 1 | 0 | ≤ 4 | No |
| Cc1−/− | HF | >3 | 3 | 2 | ≤ 2 | 0 | ≤ 7 | YES |
| Cc1−/−xliver+ | RD | >3 | 0 | ≤ 1 | 0 | 0 | ≤ 1 | No |
| Cc1−/−xliver+ | HF | >3 | 2 | ≤ 2 | 0 | 0 | ≤ 4 | No |
Male mice were fed a HF or kept on RD diet for 5 months starting at 3 months of age (n≥3–6 mice/genotype/feeding group). NAS score was evaluated based on NIH guidelines. Score did not significantly change after nicotinic acid treatment.