FIGURE 3.

MiR‐106a‐5p is the direct target of SGMS1‐AS1 and is negatively correlated with SGMS1‐AS1. (a) The ENCORI database was used to predict that SGMS1‐AS1 could bind to miR‐106a‐5p. (b) The expression of SGMS1‐AS1 was negatively related with miR‐106a‐5p by the ENCORI database. (c) MiR‐106‐5p mimics decreased the expression level of SGMS1‐AS1 3′‐UTR‐WT luciferase activity significantly whereas it had no obvious effect on 3′‐UTR‐MUT. (d, e) qRT‐PCR experiments verified the relationship between SGMS1‐AS1 and miR‐106a‐5p. (f) The mRNA level of miR‐106a‐5p was upregulated dramatically in LUAD cells compared with normal cells