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. 2021 Jul 5;9:669381. doi: 10.3389/fcell.2021.669381

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Copyright © 2021 Barachini, Montali, Panvini, Carnicelli, Gatti, Piolanti, Bonicoli, Scaglione, Buda and Parchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression profiling of cells from primary cultures. (A) BM- and UCB-derived cells showed parallel expression profiles for the 87 genes analyzed. Angiogenesis/lymphangiogenesis (gene cluster A) and MPC-related genes (gene cluster C) were significantly up-regulated in these cells, whereas, MSC-related genes (cluster B) resulted up-regulated in SVF-derived cells. (B) Single-gene expression analysis revealed significant lower expression of MCAM, WNT5B, TEK, and SIGLEC1 in UCB-derived cells as compared to BM-derived cells. Relevant reduction of stromal growth factor receptor gene expression was also detected.