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Genome wide HLODs scores for gene-based two-point linkage analysis. (A) The gene-based HLOD scores using only the rare variants (MAF ≤ 0.05) and (B) the gene-based HLOD scores using all variants. The lines at 3.3 and 1.9 represent the respective significant and suggestive thresholds as suggested by Lander and Kruglyak.
