Table 2.
All Significant and Suggestive Genes From the Gene-based Linkage Analysis
CHR | POS | GENE | CUMUL LOD | HLOD | VARIANTS |
---|---|---|---|---|---|
7 | 48.34 | CRHR2 | 3.98 | 4.06 | All |
7 | 50.78 | AVL9 | 3.99 | 3.99 | All |
9 | 59.79 | DNAI1 | 2.81 | 2.81 | All |
7 | 52.59 | NPSR1-AS1 | 2.74 | 2.74 | All |
7 | 52.05 | BMPER | 1.86 | 2.73 | All |
20 | 54.18 | BPIFA2 | 2.64 | 2.65 | All |
7 | 54.00 | SEPT7 | 2.34 | 2.61 | All |
20 | 28.26 | PAK7 | 1.75 | 2.47 | All |
1 | 49.16 | EPHB2 | 2.44 | 2.44 | All |
9 | 43.87 | FOCAD | 2.14 | 2.37 | All |
18 | 8.08 | SMCHD1 | 2.37 | 2.37 | All |
3 | 39.61 | EFHB | 1.77 | 2.36 | All |
7 | 48.59 | INMT-FAM188B | 2.35 | 2.35 | Rare |
13 | 36.59 | CSNK1A1L | 2.15 | 2.35 | All |
6 | 92.24 | COL12A1 | 2.34 | 2.34 | All |
13 | 52.86 | SETDB2 | 1.94 | 2.30 | All |
7 | 50.30 | PDE1C | 2.21 | 2.21 | All |
20 | 55.10 | CEP250 | 1.93 | 2.10 | All |
14 | 97.59 | SERPINA9 | 1.35 | 2.09 | All |
4 | 9.39 | EVC | 0.92 | 2.08 | All |
7 | 54.69 | KIAA0895 | 1.34 | 2.04 | All |
7 | 46.21 | LOC646762 | 1.49 | 1.99 | All |
7 | 48.61 | FAM188B | 1.99 | 1.99 | Rare |
9 | 111.62 | ZNF462 | 1.95 | 1.95 | All |
4 | 9.39 | EVC | 1.93 | 1.93 | Rare |
6 | 178.62 | PACRG | 0.72 | 1.92 | All |
1 | 49.16 | EPHB2 | 1.92 | 1.92 | All |
7 | 50.30 | PDE1C | 0.31 | 1.91 | All |
9 | 123.13 | AKNA | 1.90 | 1.90 | Rare |
The list of all significant and suggestive genes from the gene-based linkage analyses, as sorted by HLOD. Here the headers represent: CHR = chromosome, POS = genetic position in cM of the gene, GENE = gene, CUMUL LOD = cumulative LOD score for the gene across all 106 families, HLOD = heterogeneity LOD score for the gene across all 106 families, VARIANTS = type of variants used in this test (All = all variants were used, Rare = only rare variants (MAF ≤ 0.05) were used).