Table 3.

Univariate and multivariate analysis of clinicopathological characteristics for OS of all patients.

	Univariate analysis		Multivariate analysis
Variables	HR (95% CI)	P-value	HR (95% CI)	P-value
Age	1.296 (1.273–1.320)	<0.001	1.101 (1.080–1.122)	<0.001
Gender	0.810 (0.795–0.825)	<0.001	0.813 (0.798–0.829)	<0.001
Histology	1.159 (1.147–1.172)	<0.001	1.101 (1.089–1.113)	<0.001
Grade	1.004 (0.997–1.011)	0.251	–	–
Radiation	0.837 (0.822–0.852)	<0.001	0.958 (0.940–0.976)	<0.001
Chemotherapy	0.378 (0.371–0.385)	<0.001	0.377 (0.370–0.384)	<0.001
T stage	1.072 (1.062–1.081)	<0.001	1.053 (1.044–1.063)	<0.001
N stage	1.071 (1.063–1.080)	<0.001	1.099 (1.090–1.108)	<0.001
Metastasis site	1.046 (1.040–1.052)	<0.001	1.035 (1.029–1.042)	<0.001
Primary surgery	0.678 (0.657–0.699)	<0.001	0.665 (0.644–0.686)	<0.001