Table 3.

Outcomes

Primary endpoint  ► Alteration of transcriptomic profile of human tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing  ►Change in taste sensitivity as detected by chemical gustometry

Secondary endpoints  ► Change in neural response to visual food cues in reward processing regions as assessed by functional MRI  ► Change in body weight  ► Change in fat mass as determined by DXA  ► Change in eating behaviour

Abbreviations: RNA sequencing ribonucleic acid sequencing, DXA dual-energy X-ray absorptiometry, functional MRI functional magnetic resonance imaging