Table 4.
Issues raised on scientific review of LOIs, by subject area and outcome.
| Issue Area | Observational |
Mental Health |
Surgical |
Medical |
Overall |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Approved (4) | Disapproved (1) | Approved (6) | Disapproved (5) | Approved (6) | Disapproved (6) | Approved (10) | Disapproved (26) | Approved (26) | Disapproved (38) | |
| Investigator Qualifications | 0 | 0 | 0 | 4 | 0 | 1 | 1 | 13 | 1 | 18 |
| Feasibility within VA | 3 | 0 | 2 | 2 | 2 | 2 | 3 | 8 | 10 | 12 |
| Preliminary Data | 0 | 1 | 0 | 3 | 0 | 3 | 1 | 19 | 1 | 26 |
| Potential Ethical Issues | 0 | 0 | 0 | 2 | 0 | 3 | 1 | 10 | 1 | 15 |
| Design Concerns | 0 | 1 | 0 | 3 | 3 | 6 | 6 | 19 | 9 | 29 |
| Statistical Power | 1 | 0 | 1 | 4 | 2 | 4 | 3 | 11 | 7 | 19 |
| Competing Studies | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 2 |
| Other | 2 | 0 | 0 | 4 | 2 | 3 | 3 | 19 | 7 | 26 |
Data table includes only those LOIs that underwent scientific review.