TABLE 1.
Characteristics of patients (n = 41) | PD (n = 15) | No‐PD (n = 26) | MSA (n = 15) | PSP (n = 8) | Undefined (n = 3) | P value (PD vs. no PD) |
---|---|---|---|---|---|---|
Gender n (%) | ||||||
Male | 7 (46.7%) | 13 (50.0%) | 8 (53.3%) | 3 (37.5%) | 2 (66.7%) | 0.837 * |
Female | 8 (53.3%) | 13 (50.0%) | 7 (46.7%) | 5 (62.5%) | 1 (33.3%) | |
Age of onset (y) mean ± SD | 63.9 ± 4.6 | 66.0 ± 7.9 | 62.8 ± 7.5 | 70.6 ± 7.2 | 70.0 ± 4.6 | 0.368 ** |
Age (T1) (y) mean ± SD | 68.4 ± 6.5 | 70.1 ± 8.2 | 66.1 ± 7.2 | 75.5 ± 7.5 | 75.7 ± 1.5 | 0.493 ** |
Disease duration (T1) (y) mean ± SD | 3.5 ± 2.8 | 4.1 ± 3.2 | 3.3 ± 3.0 | 4.9 ± 3.4 | 5.7 ± 4.0 | 0.658 ** |
LED (T1) mean ± SD | 490.8 ± 195.5 | 461.8 ± 262.2 | 501.7 ± 277.3 | 410.3 ± 274.0 | 400.0 ± 173.2 | 0.720 ** |
LED (T3) mean ± SD | 636.2 ± 224.7 | 522.1 ± 251.0 | 564.5 ± 251.5 | 525.0 ± 271.2 | 300.0 ± 0 | 0.163 ** |
MIBG‐SPECT positivity | 12(80.0%) | 6 (23.1%) | 3 (20.0%) | 2 (25.0%) | 1 (33.3%) | 0.001 * |
Clinical features n (%) | ||||||
Tremoric parkinsonism (T1) | 7 (46.7%) | 6 (23.1%) | 5 (33.3%) | 1 (12.5%) | 0 (0%) | 0.168 *** |
PIGD parkinsonism (T1) | 5 (33.3%) | 11 (42.3%) | 4 (26.7%) | 6 (75.0%) | 1 (33.3%) | 0.742 *** |
Asymmetrical parkinsonism (T1) | 11 (73.3%) | 8 (30.8%) | 7 (46.7%) | 1 (12.5%) | 0 (0%) | 0.011 *** |
pRBD n (%) | 5 (33.3%) | 6 (23.1%) | 5 (33.3%) | 1 (12.5%) | 0 (0%) | 0.469 *** |
Dysautonomia (T1) | 6 (40.0%) | 17 (65.4%) | 12 (80.0%) | 5 (62.5%) | 0 (0%) | 0.191 *** |
Dysautonomia (T3) | 10 (66.7%) | 21 (80.8%) | 15 (100%) | 6 (75.0%) | 0 (0%) | 0.453 *** |
Urinary symptoms (T1) | 4 (26.7%) | 16 (61.6%) | 11 (73.3%) | 5 (62.5%) | 0 (0%) | 0.052 *** |
Urinary symptoms (T3) | 8 (53.3%) | 21 (80.8%) | 15 (100%) | 6 (75.0%) | 0 (0%) | 0.083 *** |
Orthostatic hypotension (T1) | 4 (26.7%) | 6 (23.1%) | 6 (40.0%) | 0 (0%) | 0 (0%) | 0.983 *** |
Orthostatic hypotension (T3) | 5 (33.3%) | 10 (38.5%) | 10 (66.7%) | 0 (0%) | 0 (0%) | 0.956 *** |
Response to levodopa | 8 (53.3%) | 3 (11.5%) | 3 (20.0%) | 0 (0%) | 0 (0%) | 0.007 *** |
Pearson's chi square test.
Independent samples T‐test.
Fisher's exact test.
PD, Parkinson's disease; No‐PD, total of patients with a diagnosis other than PD; MSA, multiple system atrophy; PSP, progressive supranuclear palsy; Undefined, patients with no established diagnosis; y, years; SD, standard deviation; LED, levodopa equivalent dose; PIGD, postural instability gait difficult; pRBD, probable rem behavior disorder; Bold values differ significantly by comparing the two groups of patients.