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. 2021 May 7;8(5):717–724. doi: 10.1002/mdc3.13227

TABLE 1.

Demographic and clinical characteristics of patients: comparisons between groups according to final diagnosis at T3

Characteristics of patients (n = 41) PD (n = 15) No‐PD (n = 26) MSA (n = 15) PSP (n = 8) Undefined (n = 3) P value (PD vs. no PD)
Gender n (%)
Male 7 (46.7%) 13 (50.0%) 8 (53.3%) 3 (37.5%) 2 (66.7%) 0.837 *
Female 8 (53.3%) 13 (50.0%) 7 (46.7%) 5 (62.5%) 1 (33.3%)
Age of onset (y) mean ± SD 63.9 ± 4.6 66.0 ± 7.9 62.8 ± 7.5 70.6 ± 7.2 70.0 ± 4.6 0.368 **
Age (T1) (y) mean ± SD 68.4 ± 6.5 70.1 ± 8.2 66.1 ± 7.2 75.5 ± 7.5 75.7 ± 1.5 0.493 **
Disease duration (T1) (y) mean ± SD 3.5 ± 2.8 4.1 ± 3.2 3.3 ± 3.0 4.9 ± 3.4 5.7 ± 4.0 0.658 **
LED (T1) mean ± SD 490.8 ± 195.5 461.8 ± 262.2 501.7 ± 277.3 410.3 ± 274.0 400.0 ± 173.2 0.720 **
LED (T3) mean ± SD 636.2 ± 224.7 522.1 ± 251.0 564.5 ± 251.5 525.0 ± 271.2 300.0 ± 0 0.163 **
MIBG‐SPECT positivity 12(80.0%) 6 (23.1%) 3 (20.0%) 2 (25.0%) 1 (33.3%) 0.001 *
Clinical features n (%)
Tremoric parkinsonism (T1) 7 (46.7%) 6 (23.1%) 5 (33.3%) 1 (12.5%) 0 (0%) 0.168 ***
PIGD parkinsonism (T1) 5 (33.3%) 11 (42.3%) 4 (26.7%) 6 (75.0%) 1 (33.3%) 0.742 ***
Asymmetrical parkinsonism (T1) 11 (73.3%) 8 (30.8%) 7 (46.7%) 1 (12.5%) 0 (0%) 0.011 ***
pRBD n (%) 5 (33.3%) 6 (23.1%) 5 (33.3%) 1 (12.5%) 0 (0%) 0.469 ***
Dysautonomia (T1) 6 (40.0%) 17 (65.4%) 12 (80.0%) 5 (62.5%) 0 (0%) 0.191 ***
Dysautonomia (T3) 10 (66.7%) 21 (80.8%) 15 (100%) 6 (75.0%) 0 (0%) 0.453 ***
Urinary symptoms (T1) 4 (26.7%) 16 (61.6%) 11 (73.3%) 5 (62.5%) 0 (0%) 0.052 ***
Urinary symptoms (T3) 8 (53.3%) 21 (80.8%) 15 (100%) 6 (75.0%) 0 (0%) 0.083 ***
Orthostatic hypotension (T1) 4 (26.7%) 6 (23.1%) 6 (40.0%) 0 (0%) 0 (0%) 0.983 ***
Orthostatic hypotension (T3) 5 (33.3%) 10 (38.5%) 10 (66.7%) 0 (0%) 0 (0%) 0.956 ***
Response to levodopa 8 (53.3%) 3 (11.5%) 3 (20.0%) 0 (0%) 0 (0%) 0.007 ***
*

Pearson's chi square test.

**

Independent samples T‐test.

***

Fisher's exact test.

PD, Parkinson's disease; No‐PD, total of patients with a diagnosis other than PD; MSA, multiple system atrophy; PSP, progressive supranuclear palsy; Undefined, patients with no established diagnosis; y, years; SD, standard deviation; LED, levodopa equivalent dose; PIGD, postural instability gait difficult; pRBD, probable rem behavior disorder; Bold values differ significantly by comparing the two groups of patients.