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(A) Outline of bisulfite conversion on an example DNA fragment. The red squares indicate non-nucleosomal regions recognized by CpG methyltranferases. After bisulfite conversion, cytosines are presented as uracil, which are converted into thymidine. Nucleosomal regions are discriminated from non-nucleosomal by comparing the resulting PCR product with the initial DNA sequence. (B) Chemical reaction of bisulfite-catalyzed conversion of cytosine to uracil.
