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Schematic overview of the DNA fiber approach to analyze distinct replication events. Two subsequent pulses of the thymidine analogs IdU (5-iodo-2–deoxy-uridine) and CldU (5-chloro-2-deoxy-uridine) are used to label active DNA synthesis. (A) Study of replication initiation, elongation, and termination events. (B) Determining the distance between two neighboring replication origins. (C) Investigating the effect of genotoxic stress-inducing agents on replication progression.
