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. 2021 Jul 5;11:682217. doi: 10.3389/fonc.2021.682217

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Copyright © 2021 Du, Pasca di Magliano and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Current active clinical trials targeting immunosuppressive TME in pancreatic cancer. CAF, cancer associated fibroblasts; CCL, C-C motif chemokine ligand; CCR, C-C motif chemokine receptor; CSF1R, colony-stimulating factor 1 receptor; CXCL, C-X-C motif chemokine ligand; DC, dendritic cell; IL, interleukin; MDSCs, myeloid-derived suppressor cells; PD-1, anti-programmed cell death 1; PD-L1, programmed cell death ligand 1; TAMs, tumor associated macrophages; TGF-β, transforming growth factor β; Th, T helper; Tregs, regulatory T cells.