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. 2021 Jul 5;9:676142. doi: 10.3389/fcell.2021.676142

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Copyright © 2021 Wang, Chen, Ying, Ma, Shen, Li, Wang, Lin, Liu, Zheng and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The differences of immune cell infiltration levels in two clear cell renal cell carcinoma (ccRCC) subtypes. (A–F) The infiltration level of the CD8+ T cell (A), Tregs (B), and T follicular helper cell (C) were downregulated in cluster 1 ccRCC patients. The infiltration levels of the monocyte (D), M1 macrophage cell (E), and M2 macrophage cell (F) were upregulated in cluster 1 ccRCC patients. (G) Gene set enrichment analysis indicated that ERBB signaling and the JAK-STAT signaling pathways are significantly enriched in cluster 1. NES, normalized enrichment score; q-value, false discovery rate. *p < 0.05, ***p < 0.001, and ****p < 0.0001.