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. 2021 Jul 5;9:676142. doi: 10.3389/fcell.2021.676142

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Copyright © 2021 Wang, Chen, Ying, Ma, Shen, Li, Wang, Lin, Liu, Zheng and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulated CARS expression is associated with poor outcomes of clear cell renal cell carcinoma (ccRCC). (A,B) The Kaplan–Meier analysis of ccRCC patients with high and low CARS expression level in the TCGA cohort (A) and Kaplan–Meier plotter database (B). (C) The stacked bar chart and violin plot visualized the proportion of live/death and survival time in high/low CARS groups in ccRCC patients. (D) Time-dependent receiver operating characteristics analysis of CARS and the two most common housekeeping genes, GAPDH and β-Actin. (E,F) Forest plots based upon the outcomes of univariate (E) and multivariate Cox regression (F) of CARS expression and other clinicopathological factors. *p < 0.05.