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. 2021 Jul 16;30:09636897211033778. doi: 10.1177/09636897211033778

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — SHR0302 increased Tregs and reduced Th1 cells. (A) The cell counts of bone marrow (BM) and spleen in 4 group mice: vehicle-6Ws, SHR0302-16Ws, TCD-BMT-6Ws, and healthy recipient control (n = 9 for each group) (6Ws and 16Ws: at 6th and 16th weeks after transplantation, respectively). (B) The percentages of CD3⁺ T cells and CD19⁺ B cells in spleen cells in four groups: vehicle-6Ws (n = 10), SHR0302-16Ws (n = 11), TCD-BMT-6Ws (n = 9), and healthy recipient control (n = 9). (C) The percentages of CD4⁺ T cells and CD8⁺ T cells in all T cells of spleen in four groups: vehicle-6Ws (n = 10), SHR0302-16Ws (n = 11), TCD-BMT-6Ws (n = 9), and healthy recipient control group (n = 9). (D) The percentages of CD4⁺Foxp3⁺ cells of spleen in vehicle-6Ws (n = 7), SHR0302-16Ws (n = 11), TCD-BMT-6Ws (n = 9), and healthy recipient control groups (n = 9), respectively. (E) The percentages of CD4⁺IFN-γ⁺ cells in all CD4⁺ cells of spleen in four groups: vehicle-6Ws (n = 5), SHR0302-16Ws (n = 5), TCD-BMT-6Ws (n = 3), and healthy recipient control (n = 3). (F) The percentages of CD8⁺IFN-γ⁺ cells in all CD8⁺ cells of spleen in four groups: vehicle-6Ws (n = 5), SHR0302-16Ws (n = 5), TCD-BMT-6Ws (n = 3), and healthy recipient control mice (n = 3). Data were pooled from two separate experiments in Figure A-D. Bars show the mean ± SEM. *P < 0.05.