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. 1984 Dec 1;25(4):467–479. doi: 10.1186/BF03546915

Treatment of Bovine Ketosis with Invert Sugar, Glucocorticoids, and Propylene Glycol

Behandling av ketos med invert socker, glukokortikoider och propyten glykol

Kauko Kauppinen 1,2,✉, Yrjö Gröhn 1,2
PMCID: PMC8287457  PMID: 6534159

Abstract

Four different treatments of bovine ketosis, using 3 different pharmaceutical preparations, were monitored. The main antiketogenic and glucogenic ingredients of the preparations were as follows: invert sugar (Metabol), prednisolone and dexamethasone (Predasen), the former preparations combined (Metabol & Predasen) and propylene glycol and dexamethasone (Dexaprol). Blood samples were drained from the ketotic cows prior to the treatment. The animals were sampled again 2 and 7 days after the first sampling. The whole blood concentrations of acetoacetate (AA concn), β-hydroxybutyrate (BHB concn) and glucose (glue concn) were determined. The measures of the antiketogenic and glucogenic efficacy of the various treatments applied were their ability to reduce the AA concn and BHB concn and to elevate the gluc concn.

Invert sugar (Metabol) alone had no antiketogenic efficacy, although in some cases it led to a subjective clinical improvement as reported by the owners of the animals. Invert sugar and glucocorticoids (Metabol & Predasen) dexamethasone and prednisolone (Predasen) and dexamethason plus propylene glycol (Dexaprol) were equally effective in bringing the AA, BHB and glue concns to normal range. The mean glue concn of the cows treated with Dexaprol was higher than that of the cows in the other treatment groups at 2 days (P < 0.01). No other differences between the 3 antiketogenic treatments could be shown.

Keywords: proteins, tissue cage fluid, tissue fluid

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References

  1. Baird G. D. Sc R. J. Heitzman. Mode of action of a glucocorticoid on bovine intermediary metabolism. Possible role in controlling hepatic ketogenesis. Biochim. biophys. Acta. 1971;252:184–198. doi: 10.1016/0304-4165(71)90107-3. [DOI] [PubMed] [Google Scholar]
  2. Bergman E. N., Roberts S. J. Urinary glucose excretion and blood concentrations in ketotic cattle after treatment with glucose. Cornell Vet. 1967;57:624–629. [Google Scholar]
  3. Goetsch D. G., Gravers M. S., Underbjerg K. L., Swenson M. J. The utilization of intravenously administered glucose, invert sugar and fructose in cattle. Amer. J. vet. Res. 1956;17:213–216. [PubMed] [Google Scholar]
  4. Hikosaka K., Sasaki Y., Tsuda T. Effects of glucose, insulin and FFA in food intake in sheep. Ann. Rech. Vet. 1979;10:237–239. [PubMed] [Google Scholar]
  5. Johnson R. B. The treatment of ketosis with glycerol and propylene glycol. Cornell Vet. 1954;44:6–21. [PubMed] [Google Scholar]
  6. Kauppinen K. Prevalence of bovine ketosis in relation to number and stage of lactation. Acta vet. scand. 1983;24:349–361. doi: 10.1186/BF03546709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kouider S., Kolb F. E., Müller I., Sc, Pfüller K. Untersuchungen über das Verhalten verschiedener Blutbestandteile (Glukose, Fruktose, Insulin, Laktat, Pyruvat, freie Fettsäuren, anorganisches Phosphat) und über die Halbwertzeit der Monosaccharide im Blutplasma nach i. Infusion von Glukose-, Fruktose-, Galaktose- und Invertzuckerlösung bei Wiederkäuern. [Studies into behaviour of several blood components (glucose, fructose, insulin, lactate, pyruvate, free fatty acids, and inorganic phosphate) and into half-life of monosaccharides in blood plasma following intravenous infusion to ruminants of glucose, fructose, galactose, and invert sugar solutions. 2nd communication: Testing of cattle]. Arch, exper. Vet.-med. 1978;32:699–714. [PubMed] [Google Scholar]
  8. Kronfeld, D. S. & R. S. Emery: Acetonemia. In Bovine Medicine and Surgery and Heard Health Management, Ed. W. J. Gibbons, E. J. Gatcott, and J. F. Smithcors. Amer. Vet. Publ., Wheaton, 111. 1970, p. 350–376.
  9. Kronfeld D. S. The potential importance of glucogenic, lipogenic and aminogenic nutrients in regard to the health and productivity of dairy cows. Fortschritte in der Tierphysiologie und Tierernährung. 1976;7:5–26. [PubMed] [Google Scholar]
  10. McCarthy R. D., Porter G. A., Griel L. C., Jr. Bovine ketosis and depressed fat test in milk: a problem of methionine metabolism and serum lipoprotein aberration. J. Dairy Sci. 1968;51:459–462. doi: 10.3168/jds.S0022-0302(68)87007-9. [DOI] [PubMed] [Google Scholar]
  11. McClymont G. L., Setchell B. P. Insulin induced hypoglycemic encephalopathy in the sheep and its implication as regards pathogenesis of the disease. Aust. vet. J. 1956;32:97–109. doi: 10.1111/j.1751-0813.1956.tb05634.x. [DOI] [Google Scholar]
  12. Pehrson B. The effect of orally administered glycogenic substance to dairy cows. III. Nord. Vet.-Med. 1972;24:423–426. [PubMed] [Google Scholar]
  13. Reid R. L. The physiopathology of undernourishment in pregnant sheep, with particular reference to pregnancy toxemia. Adv. Vet. Sci. 1968;12:163–238. [PubMed] [Google Scholar]
  14. Schultz L. H. Treatment of ketosis in dairy cattle with sodium propionate. Cornell Vet. 1952;42:148–155. [PubMed] [Google Scholar]
  15. Siegel, S.: Nonparametric Statistics. M. G. Graw-Hill International Book Company Tokyo, 1956.
  16. Stöckt W., Onderscheka K., Zacherl M. K. Zur Frage des Eintritts und der Dauer von Corticoidwirkungen. (Rapidity and duration of the effect of corticoid preparations) Wien, tierärztl. Mschr. 1969;56:229–232. [PubMed] [Google Scholar]
  17. Työppönen J., Kauppinen K. The stability and automatic determination of ketone bodies in blood samples taken in field conditions, Acta vet. scand. 1980;21:55–61. doi: 10.1186/BF03546900. [DOI] [PMC free article] [PubMed] [Google Scholar]

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