Figure 4.

Biomedical applications of heart-on-a-chip. (A) Physiology study. The chip was composed of four microchambers to mimic the heart and the microfluidic channels to mimic the network of blood vessels. Its function is to study the working mechanism of circulatory system (Reproduced from ref. [83] with permission from The Royal Society of Chemistry). (B) Disease model. The heart-on-a-chip was designed to model the hypoxia-induced myocardial injury (Adapted with permission from (Ren L, Liu W, Wang Y, et al., 2013, Investigation of Hypoxia-Induced Myocardial Injury Dynamics in a Tissue Interface Mimicking Microfluidic Device. Analytical Chemistry, 85(1): 235-244). Copyright (2013) American Chemical Society.) (C) Drug screening. The high-throughput chip with iPSC-CMs microtissues was used to test the effect of isoproterenol and mefloquine hydrochloride (Reproduced from ref.[72] with permission from The Royal Society of Chemistry).