Figure 2.

Outline of FEM mesh generation algorithm. The ID map defines two levels of plicate regions, such that the interplicate region mesh is defined by the region separating the two levels. The cell–cell junction distribution determines a GJ map for both plicate and interplicate regions, which defines the locations of the two membranes connecting. A 2-D sine wave function replicates the folds in the plicate membranes. A series of connecting meshes join the plicate and the interplicate region membranes, ensuring that the full mesh encloses a continuous volume (i.e., the mesh is “waterproof”). Combining all of these mesh components generates the cleft mesh.