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. 2021 Jul 15;153(8):e202112897. doi: 10.1085/jgp.202112897

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© 2021 Moise et al.

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Figure 8. — Membrane and cleft dynamics during electrical conduction in the cleft network model for the following cases.(A) High GJ coupling, narrow interplicate. (B) Weak GJ coupling, narrow interplicate. (C) Strong GJ coupling, wide interplicate. (D) Weak GJ coupling, wide interplicate. Top in each panel: Transmembrane potential ϕ_m (black, for cells 25 and 26; gray for upstream and downstream cells), cell 25 prejunctional (right, I_Na, cyan) and cell 26 postjunctional (left, I_Na, magenta) Na⁺ current, GJ current (orange). Bottom in each panel: Cleft potential ϕ_c, and cleft [Na⁺] for all cleft compartments are shown as a function of time. Dark cyan and magenta curves represent the mean pre- and postjunctional I_Na, respectively. Parameters: M = 100; plicate distance d_P = 30 nm; gap junctional conductance g_gap (nS): A and C, 388; B and D, 38.8; interplicate distance d_Ip (nm): A and B, 15; C and D, 60.