Table 4.
Summary of main effects and interactions of predictors on WMH volume in periventricular and deep regions.
| WMH Location | Periventricular | Deep | ||||
|---|---|---|---|---|---|---|
| Predictors | Beta | F-value | p-value | Beta | F-value | p-value |
| Age | 0.016 | 3.453 | 0.065 | 0.008 | 0.341 | 0.529 |
| Sex | −0.278 | 6.657 | 0.009* | −0.008 | 0.002 | 0.966 |
| ICV | 0.126 | 5.867 | 0.010* | 0.118 | 1.848 | 0.170 |
| CBF | −0.132 | 8.387 | 0.011* | −0.074 | 0.902 | 0.344 |
| QSM | 0.052 | 0.883 | 0.414 | 0.236 | 6.841 | 0.034* |
| RD | 0.214 | 16.486 | <0.001* | 0.217 | 6.908 | 0.023* |
| CBF × QSM | −0.047 | 0.814 | 0.482 | −0.054 | 0.312 | 0.562 |
| QSM × RD | −0.028 | 0.125 | 0.755 | 0.062 | 0.339 | 0.593 |
| CBF × RD | 0.013 | 0.105 | 0.744 | 0.012 | 0.024 | 0.880 |
Displayed are unstandardized beta, F-and p-values for the main effects of all predictors, and interaction effects in both PV (left) and deep (right) WMH models. QSM was positively associated with deep but not PV WMH volume, while RD strongly predicted both. CBF negatively predicted PV WMH volume. There were no interactions between predictors in either model.
*
p < 0.05.