Table 1. Correlation between vtRNA promoters ATAC-seq and DNA methylation values in the Pan-Cancer TCGA samples.

	Average ± SD		Spearman correlation (ATAC-seq vs DNA methylation)
vtRNA	Promoter ATAC-seq	Promoter DNA methylation	Rs	p-value
vtRNA1-1	4.1 ± 0.6	0.09 ± 0.07	-0.24	<0.0001
vtRNA1-2	2.9 ± 1.6	0.42 ± 0.20	-0.74	<0.0001
vtRNA1-3	1.7 ± 1.2	0.22 ± 0.15	-0.54	<0.0001
vtRNA2-1	2.5 ± 1.4	0.47 ± 0.21	-0.78	<0.0001

The Spearman correlation was calculated for the 329 primary tumors studied by ATAC-seq and DNA methylation.