Table 3A.
Immune gene categories involved in differentially expressed mRNA for comparison groups SvC-B, SvC-N, and SvS-BvN-D7.
| Compared group | Immune gene category | |
|---|---|---|
| 1<FC<2 | 2<FC | |
| Up-regulated in group SvC-B (26) | LRR-containing proteins, MRC, NFIL3, perforin, UBE, PIGR, TRIM, TLX. | CSF, UBE, C3, GVIN, IL21R, IL23R, integrin alpha, MMR, NCAM, cathepsin, ubiquitin ligase ladderlectin, LRR-containing proteins, Ig heavy chain, Ig light chain, PIGR, SEMA. |
| Down-regulated in group SvC-B (23) | CXCL, integrin alpha, myeloid cell related, galectin. | Fibrinogen, NALP12, NLRC3, C3, GVIN, IFI, IL1R, C-type lectin, galectin, TLR18, Ig light chain, TIP. |
| Up-regulated in group SvC-N (155) | FBXL, fucolectin, MPR, nattectin, TLR1, TLR5, CDK, CDK related, CDKIs, HA, MHC I, MHC II, TGFB, TNF, TNFAIP3-interacting protein, C3aR, C7, CCL, CCR, CFLAR, CXCL, CXCR, cytokine receptor, IFI, IFIT, IL1R related, IRF8, NFIL3, MAPK, MAPKKK, NALP12, NLRC3, programmed cell death protein, SOCS1, SOCS3, SOCS7, TRAF, TTRAP, UBE, MIF, NCF, NCK and related, BCL, BLNK, FCR, HDAC, HMG, Ig light chain, PBX, TAGAP, AP-3, CARD, cathepsin, CEBP, hepcidin, HSP, lymphocyte antigen, myeloid cell related, PIN1, platelet related, TMED, ubiquitin ligase, ubiquitin related, TRIM, UBL. | MAPK, MAPKKK, NLRC3, MHC II, C3, CCL, CXCL, CXCR, IL-1, IL1R, IL-6, IL6R, IL-8, IRF8, MX, NRAMP, AP-3, cathepsin, HSP5, HSP70, mucin, myeloid cell related, platelet related, ubiquitin ligase, NITR, TLR18, TLR22, TLR25, CD22, HMG, TCIRG1, |
| Down-regulated in group SvC-N (102) | Plasminogen, C-type lectin, Hepatic lectin, LRR-containing proteins, RBL, SITR, TLR13, CD22, Ig heavy chain, Ig light chain, SEMA, TCR, CDK, VEGF, VEGFR, C3aR, ACRs, CCR, EGFR, FGFR, GVIN, IL17R, IL21R, IL2R, integrin alpha, integrin beta, ACTININ, MALT1, paladin, RTK, TRIM, ubiquitin ligase, UBL, granzyme, MAPKKK, NALP12, NALP3, perforin, UBE, CDK, TRIM. | perforin, CD59, CCL, IL6R, IL-8, IRF related, TITIN, NCAM, CD33, HSP90, Kruppel-like factor, ubiquitin ligase, UBL, collectin, galectin, LRR-containing proteins, B-cell CLL/lymphoma, JAG, NFAT, SEMA |
| BS-advantage immune DEGs in group SvS-BvN-D7 (357) | Fibrinogen, MBL, collectin, C-type lectin, FBXL, fucolectin, galectin, intelectin, LRR-containing proteins, RBL, TLR8, TLR13, TLR3, TLR9, CDKIs, CIITA, LRMP, TGBR, VEGF, C3, C5, ACRs, CCL, CCR, CXCR, EGF, FGFR, GVIN, IFI, IL10R, IL13R, IL17R, IL1R related, IL21R, IL23R, IL2R, IL6R, IL-8, integrin alpha, integrin beta, IRF4, IRF5, IRF7, MX, XCR, CBX4, CSFR, granzyme, MAPK, MAPKKK, NALP12, NALP3, NDRG1, perforin, Programmed cell death protein, TRAF, TRAIL, UBE, MMR, NCAM, B-cell CLL/lymphoma, CD2, CD22, CD276, CD6, FCR, GATA and related, Ig heavy chain, Ig light chain, immunoglobulin superfamily, JAG, LAG, MAL, NFAT, PIGR, PKC, SEMA, T-bet, VTCN, ZAP, ACTININ, cathepsin, CD302, lymphocyte antigen, lymphocyte related, myeloid cell related, nectin, palladin, PI3K, TIAM, ubiquitin ligase, ubiquitin related, TRIM. | Fibrinogen, CSF, granzyme, MAPKKK, NALP12, NALP3, NLRC3, EGF, perforin, TRAF, UBE, CDK, LRMP, MHC I, MHC II, C3aR, C8, CCL, CCR, FGFR, GVIN, IFI, IFIT, IL17R, IL1R related, IL21R, IL23R, IL2R, IL6R, IL-8, integrin alpha, integrin beta, NFIL3, TITIN, MCP, NCAM, cathepsin, HSPb1, lymphocyte antigen, mucin, PI3K, rootletin, RTK, TRIM, ubiquitin ligase, ubiquitin related, UBL, collectin, c-type lectin, fucolectin, Lgals3bpa, galectin, Hepatic lectin, ladderlectin, LRR-containing proteins, MRC, NITR, scavenger receptor, SIGLEC, CD22, CD4, FCR, HDAC, Ig heavy chain, Ig light chain, immunoglobulin superfamily, JAG, NFAT, PIGR, PKC, SEMA, VSIG. |
| NBS-advantage immune DEGs in group SvS-BvN-D7 (303) | c-type lectin, FBXL, LPS-anchor protein, LRR-containing proteins, MPR, TLR1, TLR22, CDK, CDK related, CDKIs, HA, MHC II, TGFB, TNFAIP3-interacting protein, C3, C3aR, C4, C7, ACRs, CD11, CFLAR, CXCR, cytokine receptor, FAM, GVIN, HB-EGF, IL12R, IL1R related, IL-6, IL6R, integrin alpha, integrin beta, IRF1, IRF8, NFIL3, CSFR, JAK1, MAPK, MAPKKK, NALP12, NALP3, NLRC3, Programmed cell death protein, SOCS1, SOCS3, SOCS7, STAT3, UBE, MIF, NCF, NCK and related, BAFF, B-cell CLL/lymphoma, BCL, BLNK, CD22, CD276, FCR, HDAC, HMG, Ig light chain, PBX, PIGR, SEMA, TAL, VSIG, WWP, AP-3, CARD, cathepsin, CEBP, HSP, HSP4, HSP5, HSP70, HSP90, Kruppel-like factor, lymphocyte antigen, MALT1, mucin, myeloid cell related, PAXILLIN, PIN1, platelet related, TMED, ubiquitin ligase, ubiquitin related, TRIM, UBL. | Macroglobulin, CSF, MAPK, MAPKKK, NALP12, NALP3, NLRC3, SOCS3, UBE, CDK, CDKIs, MHC II, TNF, FGF, TNFAIP3-interacting protein, C3, C3aR, C7, CD59, CCL, CCR, CXCL, CXCR, GVIN, IL-1, IL-12, IL1R, IL1R related, IL2R, IL-6, IL-8, integrin alpha, IRF8, NFIL3, NRAMP, ACTININ, AP-3, caspase, cathepsin, CEBP, hepcidin, HSP70, lymphocyte antigen, ubiquitin ligase, UBL, CD209, C-type lectin, galectin, intelectin, LRR-containing proteins, TLR18, TLR25, TLR4, TLR5, BCL, CD22, CD276, HDAC, Ig light chain, PIGR, SEMA, TAGAP, TCIRG1, TCIRG2, TCIRG3. |
For group SvS-BvN-D7, “BS-advantage” represented the upregulated genes related to the breeding strain, while “NBS-advantage” represented the downregulated genes related to non-breeding strain, after the comparison between survivors from breeding strain and survivors from the non-breeding strain.