Table 1.
Demographics and clinical characteristics of the study cohort.
| Combined cohort (N = 133) | Younger adults(N = 60) | Older adults (N = 73) | p-value | |
|---|---|---|---|---|
| Baseline (BL) vs. follow-up (FU) visit (BL/FU) | 23/110 | 3/57 | 20/53 | - |
| Age (years) | 60.7 ± 9.3 (40, 82) | 52.1 ± 4.6(40, 59) | 67.7 ± 5.5 (60, 82) | <0.0001 |
| Sex (%F) | 43.6 | 43.3 | 43.8 | 1 |
| MMSE | 29.4 ± 1.1 (25, 30) | 29.8 ± 0.6(27, 30) | 29.1 ± 1.3 (25, 30) | <0.001 |
| Phonemic fluency (words) | 36.4 ± 12.8 (11, 72) | 39.9 ± 10.8(16 69) | 33.5 ± 13.7 (11, 72) | 0.003 |
| WAIS-III Information | 17.1 ± 5.8(5, 27) | 17.4 ± 5.2(7, 25) | 16.7 ± 6.3(5, 27) | 0.5 |
| FWD (mm) | 0.07 ± 0.02 (0.03, 0.16) | 0.07 ± 0.03(0.03, 0.16) | 0.07 ± 0.02 (0.03, 0.13) | 0.07 |
N, sample size; F, female; MMSE, mini mental state examination; WAIS-III, Wechsler Adult Intelligence Scale; FWD, framewise displacement. All continuous variables are reported as mean ± standard deviation (range). Group differences between younger adults and older adults were assessed using hypothesis testing with two sample t-test for continuous variables and Fisher exact test for categorical variables. In bold, p ≤ 0.05 for easier discrimination.