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. 2021 Jul 5;12:670219. doi: 10.3389/fimmu.2021.670219

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Copyright © 2021 Petermann, Orfanos, Sellau, Gharaibeh, Lotter, Fleischer and Keller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Delayed development of inflammatory milieu in lungs of O. tsutsugamushi CCR2^-/- mice. CCR2^-/- and C57BL/6 mice were infected with 5,000 sfu O. tsutsugamushi i.d. and sacrificed on days 0, 10, 14, 17 and 21 p.i. From homogenates of lung tissue, transcription of ifn-γ, inos and tnf-α, il-4, arg1 and ccl2 mRNA was measured by real-time PCR from tissue lysates and expressed as -fold induction at the indicated time points p.i. (A–F). Shown are pooled results from two independent experiments (total of n=6 mice per genotype and timepoint; mean ± SD). *p < 0.05; **p < 0.01; ***p < 0.001 by one-way ANOVA.