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Applications of in vivo direct neuronal reprogramming to treat injury and/or neurodegenerative disease. Direct neuronal reprogramming has therapeutic potential for brain injury (e.g., glial scars, stroke) and neurodegenerative diseases, such as PD, HD, and ALS. The advantage of this approach is that endogenous glial cells can be directly reprogrammed to replace lost neurons at the site of injury or trauma.
