Table 2.
Single-exposure associationsa between early life exposures and fluid intelligence (CPM) as assessed by the ExWAS or DSA approaches. Only exposures with uncorrected p-values<0.05 or selected from DSA are shown.
| ExWAS |
DSA |
|||||
|---|---|---|---|---|---|---|
| p | Adjusted coefficient (95% CI) | Significant after p-value correction? | Frequency (%) of selection | |||
| Prenatal Exposome | TEF=0.001 | |||||
| Facility density (300 m) | 0.013 | 0.509 | (0.109 | 0.910) | No | 2 |
| Mercury | 0.014 | 0.611 | (0.122 | 1.099) | No | 6 |
| PFOA | 0.024 | 0.451 | (0.061 | 0.842) | No | – |
| PFhXS | 0.039 | 0.381 | (0.019 | 0.743) | No | – |
| NDVI (100 m) | 0.044 | −0.722 | (−1.424 | −0.021) | No | – |
| Childhood Exposome | TEF= 0.0007 | |||||
| Organic food intake | <0.001 | NA | NA | NA | Yes | 94 |
| 2nd tertile vs. 1st tertile | <0.001 | 1.255 | (0.632 | 1.878) | – | – |
| 3rd tertile vs. 1st tertile | <0.001 | 1.332 | (0.642 | 2.022) | – | – |
| House crowding | 0.001 | −0.412 | (−0.646 | −0.178) | Yes | 66 |
| Fastfood intake | 0.002 | NA | NA | NA | No | 58 |
| 2nd tertile vs. 1st tertile | 0.729 | 0.095 | (−0.444 | 0.635) | – | – |
| 3rd tertile vs. 1st tertile | 0.001 | −1.434 | (−2.294 | −0.575) | – | – |
| Lead | 0.003 | −0.436 | (−0.724 | −0.149) | No | 2 |
| ETS | 0.003 | −0.816 | (−1.354 | −0.279) | No | 44 |
| PFOS | 0.006 | 0.501 | (0.143 | 0.860) | No | 20 |
| Soda intake | 0.022 | NA | NA | NA | No | – |
| 2nd tertile vs. 1st tertile | 0.061 | −0.530 | (−1.083 | 0.023) | – | – |
| 3rd tertile vs. 1st tertile | 0.007 | −0.859 | (−1.486 | −0.231) | – | – |
| Indoor benzene | 0.014 | −0.438 | (−0.789 | −0.087) | No | – |
| Arsenic | 0.018 | 0.515 | (0.088 | 0.942) | No | – |
| PCB 180 | 0.031 | 0.509 | (0.047 | 0.972) | No | – |
| DETP | 0.034 | 0.419 | (0.031 | 0.806) | No | – |
| PFOA | 0.036 | 0.348 | (0.023 | 0.674) | No | – |
| PCB 170 | 0.037 | 0.456 | (0.028 | 0.884) | No | – |
| OXBE | 0.039 | −0.334 | (−0.651 | −0.016) | No | – |
| KIDMED score | 0.040 | 0.301 | (0.014 | 0.588) | No | – |
| HCB | 0.040 | 0.360 | (0.017 | 0.702) | No | – |
| Population density (school) | 0.043 | 0.350 | (0.010 | 0.690) | No | – |
| PFhXS | 0.048 | 0.446 | (0.005 | 0.887) | No | – |
a
Linear regression models adjusted for cohort, maternal education, maternal age, child age, sex, and trimester of conception.