Table 3.
Single-exposure associationsa between early life exposures and ANT HRT-SE (inattentiveness) as assessed by the ExWAS or DSA approaches. Only exposures with uncorrected p-values<0.05 or selected from DSA are shown.
| ExWAS |
DSA |
||||||
|---|---|---|---|---|---|---|---|
| p | Adjusted coefficient (95% CI) | Significant after p-value correction? | Frequency (%) of selection | ||||
| Prenatal Exposome | TEF=0.001 | ||||||
| Alcohol intake | 0.002 | −14.572 | (−23.930 | −5.214) | No | 26 | |
| NDVI (100 m) | 0.013 | 15.523 | (3.247 | 27.800) | No | 46 | |
| DMTP | 0.075 | −5.276 | (−11.095 | 0.543) | No | 6 | |
| Childhood Exposome | TEF=0.0007 | ||||||
| MEHP | 0.006 | 7.800 | (2.271 | 13.328) | No | – | |
| MiBP | 0.010 | 8.663 | (2.096 | 15.230) | No | – | |
| UV – Vitamin D (day) | 0.015 | 9.260 | (1.804 | 16.717) | No | – | |
| MEHHP | 0.017 | 7.005 | (1.243 | 12.767) | No | – | |
| Family affluence score | 0.057 | NA | NA | NA | No | – | |
| Middle vs. Low | 0.020 | −17.529 | (−32.351 | −2.707) | – | – | |
| High vs. Low | 0.125 | −12.049 | (−27.430 | 3.332) | – | – | |
| MEOHP | 0.023 | 6.832 | (0.964 | 12.699) | No | – | |
| Breastfeeding duration (days) | 0.053 | NA | NA | NA | No | – | |
| 2nd tertile (10.8–34.9) vs. 1st tertile (<10.8) | 0.025 | 12.868 | (1.591 | 24.146) | – | – | |
| 3rd tertile (>34.9) vs. 1st tertile (<10.8) | 0.673 | 2.595 | (−9.477 | 14.668) | – | – | |
| Bread intake | 0.029 | NA | NA | NA | No | – | |
| 2nd tertile vs. 1st tertile | 0.221 | 5.992 | (−3.614 | 15.599) | – | – | |
| 3rd tertile vs. 1st tertile | 0.080 | −10.178 | (−21.578 | 1.222) | – | – | |
| OH-MiNP | 0.035 | 5.354 | (0.375 | 10.333) | No | – | |
| Sweets intake | 0.077 | NA | NA | NA | No | – | |
| 2nd tertile vs. 1st tertile | 0.039 | −10.491 | (−20.472 | −0.510) | – | – | |
| 3rd tertile vs. 1st tertile | 0.821 | −1.218 | (−11.785 | 9.348) | – | – | |
| DEHP (sum of metabolites) | 0.042 | 6.202 | (0.223 | 12.181) | No | – | |
| Molybdenum | 0.042 | 3.546 | (0.125 | 6.967) | No | – | |
| Walkability index | 0.045 | −6.522 | (−12.903 | −0.142) | No | – | |
| Meat intake | 0.114 | NA | NA | NA | No | – | |
| 2nd tertile vs. 1st tertile | 0.049 | −10.254 | (−20.444 | −0.064) | – | – | |
| 3rd tertile vs. 1st tertile | 0.754 | −1.561 | (−11.337 | 8.214) | – | – | |
a
Linear regression models adjusted for cohort, maternal education, maternal age, child age, sex, and trimester of conception.