Table 4.
Single-exposure associationsa between early life exposures and N-Back d’ (working memory) as assessed by the ExWAS or DSA approaches. Only exposures with uncorrected p-values<0.05 or selected from DSA are shown.
| ExWAS |
DSA |
|||||
|---|---|---|---|---|---|---|
| p | Adjusted coefficient (95% CI) | Significant after p-value correction? | Frequency (%) of selection | |||
| Prenatal Exposome | TEF = 0.001 | |||||
| Inverse distance to nearest road | 0.017 | 0.101 | (0.018 | 0.183) | No | – |
| Childhood Exposome | TEF=0.0007 | |||||
| Organic food intake | 0.006 | NA | NA | NA | No | 12 |
| 2nd tertile vs. 1st tertile | 0.977 | −0.002 | (−0.160 | 0.155) | – | – |
| 3rd tertile vs. 1st tertile | 0.009 | 0.240 | (0.061 | 0.418) | – | – |
| Indoor PM2.5 | 0.006 | −0.095 | (−0.164 | −0.027) | No | 6 |
| DDE | 0.009 | 0.130 | (0.032 | 0.227) | No | 2 |
| Vegetables intake | 0.038 | NA | NA | NA | No | – |
| 2nd tertile vs. 1st tertile | 0.011 | 0.219 | (0.050 | 0.389) | – | – |
| 3rd tertile vs. 1st tertile | 0.494 | 0.050 | (−0.093 | 0.192) | – | – |
| KIDMED score | 0.018 | 0.089 | (0.015 | 0.163) | No | – |
| DDT | 0.020 | 0.124 | (0.020 | 0.229) | No | – |
| NO2 (year) | 0.026 | −0.220 | (−0.414 | −0.026) | No | – |
| MnBP | 0.027 | −0.097 | (−0.183 | −0.011) | No | – |
| Indoor PMabsorbance | 0.036 | −0.073 | (−0.142 | −0.005) | No | – |
| Total fat intake | 0.116 | NA | NA | NA | No | – |
| 2nd tertile vs. 1st tertile | 0.276 | 0.094 | (−0.075 | 0.263) | – | – |
| 3rd tertile vs. 1st tertile | 0.039 | 0.192 | (0.010 | 0.373) | – | – |
a
Linear regression models adjusted for cohort, maternal education, maternal age, child age, sex, and trimester of conception.