Table 3.
Virus replication in lung tissue of vaccinated and control mice groups post-SARS-COV 2 challenge infection
| lungs | Vero cell cultures | ||||
|---|---|---|---|---|---|
| Mice groups | Days post-challenge | No. infected/ no. tested |
Viral RNA |
No. infected/ no. tested |
Mean virus titer* |
| Unvaccinated | 3 | 4/4 | +VE | 4/4 | 2.5 |
| 7 | 3/3 | +VE | 3/3 | 5.4 | |
| Vaccinated (55 μg/dose) |
3 7 |
0/4 0/3 |
−VE −VE |
0/4 0/3 |
< 1** |
| Vaccinated (100 μg/dose) |
3 7 |
0/4 0/3 |
−VE −VE |
0/4 0/3 |
< 1** |
*Virus titers are expressed as log10 TCID50/ml of homogenized lung tissue.
**Virus not detected by the absence of CPE in infected Vero cell monolayer cultures.