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. 2021 Jul 5;12:682255. doi: 10.3389/fmicb.2021.682255

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Copyright © 2021 Yang, Haque, Matsuzaki, Matsumoto and Nakamura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of viable bacteria and phage in the lungs and serum of mice 24 h after infection. The number of viable bacteria in the lungs (A), the phage treatment group (n = 6) was significantly lower than that of the control group (n = 6). The number of viable bacteria in the serum (B), the phage treatment group (n = 6) was also significantly lower than that of the control group (n = 6). Data are presented as mean ± SEM of two experiments. The number of viable phages in the lungs and serum (C) of phage-treated mice 24 h after infection. Data are presented as mean ± SEM of two experiments (** < 0.01 vs. untreated control). CFU denotes colony forming unit. PFU denotes plaque forming unit.