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. 2021 Jul 19;19:219. doi: 10.1186/s12951-021-00961-x

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© The Author(s) 2021

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Fig.5 — In vitro and in vivo toxicity evaluation of Au@ZIF-8 nanoparticles. a The haemolysis result of Au@ZIF-8 with different concentrations. b The body weight changes of mice with different treatments over 15 days. The blood biochemistry analysis for c liver functions, d kidney functions and e blood fat levels at day 15 after treatments. uric acid, UA; blood urea nitrogen, UREA; alanine transaminase, ALT; aspartate transaminase, AST; alkaline phosphatase, ALP; total protein, TP; triglyceride. f Haematoxylin and eosin (H&E) staining images of major organs (heart, liver, spleen, lung, and kidney) of mice treated with different doses of Au@ZIF-8 nanoparticles. Data was represented as mean ± SD (n = 4). Scar bar: 200 μm