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. 2021 Jul 5;13:680621. doi: 10.3389/fnsyn.2021.680621

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Copyright © 2021 Walia, Lee, Hartsock, Goodman, Dolle, Salt, Lichtenhan and Rutherford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LC/MS calibration curves for IEM-1925 and IEM-1460. (A) The LC/MS calibration curve showing the relative area of IEM-1925 to internal standard (verapamil) in blood is plotted against IEM-1925 concentration. Replicates for each concentration were obtained with duplicate injections. The 1 ng/mL standard in blood chromatogram with S/N ~ 3.1 is shown in the inset that eluted at 1.73 min. (B) Similarly, LC/MS calibration curve showing IEM-1925 in CSF matrix is plotted against the internal standard. The 1 ng/mL standard in CSF with S/N ~3.2 is shown in the inset eluting at 1.74 min. (C) IEM-1460 calibration curve in blood with inset showing 1 ng/mL IEM-1460 in blood with S/N ~3.8 eluting at 1.78 min. (D) IEM-1460 calibration curve in CSF with inset showing 1 ng/mL IEM-1460 in CSF with S/N ~ 4.2 eluting at 1.78 min.