Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 5;13:680621. doi: 10.3389/fnsyn.2021.680621

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Walia, Lee, Hartsock, Goodman, Dolle, Salt, Lichtenhan and Rutherford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cochlear and cardiopulmonary physiology during systemic IEM-1460 or IEM-1925. (A) CAP amplitude over time, showing significant reduction after intraperitoneal (IP) injection of drug (p < 0.001, Wilcoxon, N = 4). Stimuli were 8 kHz tone bursts at 90 dB SPL. N = 4 animals per compound. (B) Heart rate and blood oxygen level before and after IP injection of drug or vehicle control in an exemplary experiment where heart rate was temporarily reduced by 15% (p < 0.001, Wilcoxon, N = 4) following IP injection of 13.5 mg/kg IEM-1460 (red trace). (C) CAP threshold as a function of cochlear frequency was not significantly different after systemic injection of IEM-1925 (p > 0.100 across all tested frequencies, Mann-Whitney U, N = 4).