eTable 2. Average annual percent change in incidence of and mortality from colorectal cancer in Germany, stratified by sex.

	AAPC [95% CI]
	Men	Women
Incidence (2000–2016)
Colorectal cancer	–1.8 [–2.3; –1.4]	–2.2 [–2.6; –1.8]
Proximal colon cancer	–0.2 [–0.7; 0.3]	–0.5 [–0.9; –0.2]
Distal colon cancer	–3.0 [–3.4; –2.5]	–3.7 [–4.1; –3.3]
Rectal cancer	–2.1 [–2.5; –1.6]	–2.7 [–3.3; –2.1]
Mortality (2000–2018)
Colorectal cancer	–2.5 [–2.7; –2.3]	–3.0 [–3.2; –2.8]
Colon cancer	–3.1 [–3.3; –2.9]	–3.3 [–3.6; –3.1]
Rectal cancer	–1.5 [–1.7; –1.2]	–2.1 [–2.3; –2.0]

AAPC, Average annual percent change; CI, confidence interval