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Lung tumor microenvironmental factors associated with exosomal metastatic promoting effects. Several factors, classified as growth/cytokine factors, exosomal cargoes, genes, pathways/axes, and receptors are directly or indirectly influenced by exosomes to participate in the promotion of lung tumor metastasis. Distant organs commonly prone to lung tumor metastasis include the liver, bone, kidney, brain, and other the contralateral unaffected lung
