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. Author manuscript; available in PMC: 2021 Sep 14.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Jul 14;59(38):16651–16660. doi: 10.1002/anie.202006278

Scheme 3.

Scheme 3.

Synthetic applications of stereodivergent alkyne hydrofluorination. a, The late-stage modification of biologically active molecules or complex natural products. b, The synthesis of different fluorinated analog of drug molecules. c, The preparation of key intermediate for the synthesis of antimicrobial agents with high regio- and Z/E-selectivities. See supporting information for detailed conditions.