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. 2020 Jul 3;27(3):388–406. doi: 10.1093/ibd/izaa161

FIGURE 2.

FIGURE 2.

The anti-inflammatory effects of APX3330 treatment in the colon of Winnie mice. A, and A’) CD45+ leukocytes were labeled using a leukocyte marker anti-CD45+ (green) antibody in the colon cross-sections. Mucosal epithelial cells are labeled with nuclei marker DAPI (blue; A: scale bar = 50 µm, 40x magnification; A’: scale bar = 30 µm, 60x magnification). B, Density of CD45+-IR cells normalized to the width of the colon sections in C57BL/6 control, Winnie sham-treated and Winnie APX3330-treated mice (n = 5/group). C, Lipocalin-2 (Lcn-2) levels in fecal pellets were quantified from C57BL/6 control, Winnie sham-treated, and Winnie APX3330-treated mice (n = 5/group). Data expressed as mean ± SEM, **P < 0.01, ***P < 0.001 compared with C57BL/6 control mice; ^^P < 0.01 compared with Winnie sham-treated mice.