FIGURE 4.

The effects of APX3330 treatment on parameters of colonic motility. A, Video recordings from ex vivo whole colon samples were transposed into spatiotemporal maps. Contractions were distinguished as red and relaxation as blue from C57BL/6 control, Winnie sham-treated, and Winnie APX3330-treated mice (n = 6/group). B, Average length of contractions in proportion to the whole colon length C. Average length of colonic migrating motor complexes (CMMCs, white arrows in A) defined as contractions initiated from the oral end that propagated toward the anal end for >50% of the colon length. D, Speed of propagation of CMMCs. E, Frequency of CMMCs quantified as the number of contractions per 10 minutes. Data expressed as mean ± SEM, *P < 0.05, ****P < 0.0001 compared with C57BL/6 control mice; ^P < 0.05, ^^^^P < 0.0001 compared with Winnie sham-treated mice.