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The m6A RNA MTase loops. The active site loop (cyan), catalytic loop (red) and substrate binding loop (green) is shown on each structurally and functionally characterized m6A RNA MTase described herein. For hMETTL16, the active site loop covers the entire N-terminal extension. For comparison, the MTDs (blue) are positioned with similar cofactor (yellow) orientation. hMETTL14, without cofactor, is oriented as hMETTL3. ec: E. coli, h: human.
