Table 2.
Comparison of the methyltransferase domain (MTD) of structurally and functionally characterized methyltransferases (MTases)
| MTase | PDB | MTD residues | Z-score | RMSD (Å) | αC-atoms | Seq. iden. (%) |
|---|---|---|---|---|---|---|
| hMETTL3 | 5IL1 | 369–570 | ||||
| Comparison with the METTL3 MTD | ||||||
| hMETTL14 | 5IL1 | 166–402 | 22.9 | 2.4 | 236 | 34 |
| hMETTL16 | 6DU4 | 78–299 | 3.4 | 3.5 | 213 | 9 |
| hCAPAM | 6IRW | 479–668* | 2.9 | 4.6 | 188 | 7 |
| hMETTL5 | 6H2V | 2–209 | 3.7 | 4.0 | 209 | 9 |
| hZCCHC4 | 6UCA | 163–375 | 2.5 | 3.7 | 214 | 5 |
| ecRlmJ | 4BLV | 1–46+99–280 | 3.2 | 3.5 | 229 | 12 |
*L483-L489 modelled from zfCAPAM (PDB 6IRX). Seq. iden.: sequence identity. Values are deduced from DALI comparison (online DALI server, pairwise comparison) (85). ‘αC-atoms’ denotes the number of αC atoms that have been superimposed to obtain the stated root mean square deviation (RMSD).