Table 3.
Mediating effect | Direct effect | Total effect | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Personality traits | MV | Estimate | 95% CI | p | Estimate | 95% CI | p | Estimate | 95% CI | p |
Conscientiousness | ||||||||||
Disease burden | 0.021 | 0.012 to 0.030 | <.001 | 0.154 | 0.087 to 0.222 | <.001 | 0.175 | 0.107 to 0.143 | <.001 | |
Depression | 0.055 | 0.042 to 0.069 | <.001 | 0.110 | 0.041 to 0.178 | .009 | 0.165 | 0.097 to 0.233 | <.001 | |
Cognition | 0.005 | −0.001 to 0.011 | .197 | 0.170 | 0.103 to 0.237 | <.001 | 0.175 | 0.107 to 0.233 | <.001 | |
Physical inactivity | 0.015 | 0.006 to 0.025 | .007 | 0.158 | 0.091 to 0.226 | <.001 | 0.174 | 0.106 to 0.241 | <.001 | |
Smoking | 0.013 | −0.002 to 0.038 | .168 | 0.171 | 0.104 to 0.238 | <.001 | 0.184 | 0.115 to 0.253 | <.001 | |
Handgrip strength | 0.004 | 0.000 to 0.009 | .140 | 0.171 | 0.103 to 0.238 | <.001 | 0.175 | 0.107 to 0.242 | <.001 | |
All mediators | 0.080 | 0.059 to 0.101 | <.001 | 0.095 | 0.026 to 0.164 | .023 | 0.175 | 0.106 to 0.245 | <.001 | |
Neuroticism | ||||||||||
Disease burden | 0.023 | 0.015 to 0.031 | <.001 | 0.116 | 0.060 to 0.171 | .001 | 0.139 | 0.084 to 0.194 | <.001 | |
Depression | 0.089 | 0.069 to 0.109 | <.001 | 0.044 | −0.014 to 0.102 | .221 | 0.133 | 0.078 to 0.188 | <.001 | |
Cognition | 0.003 | −0.001 to 0.006 | .205 | 0.137 | 0.082 to 0.192 | <.001 | 0.140 | 0.085 to 0.195 | <.001 | |
Physical inactivity | 0.010 | 0.004 to 0.016 | .006 | 0.131 | 0.076 to 0.186 | <.001 | 0.141 | 0.086 to 0.196 | <.001 | |
Smoking | 0.019 | 0.004 to 0.034 | .035 | 0.135 | 0.080 to 0.190 | <.001 | 0.154 | 0.097 to 0.211 | <.001 | |
Handgrip strength | 0.010 | 0.004 to 0.016 | .007 | 0.129 | 0.072 to 0.186 | <.001 | 0.141 | 0.086 to 0.196 | <.001 | |
All mediators | 0.121 | 0.096 to 0.146 | <.001 | 0.024 | −0.034 to 0.082 | .492 | 0.146 | 0.088 to 0.203 | <.001 |
Notes. Conscientiousness scores were reverse-coded for ease of interpreting the direction of effects. MV = mediating variable.