Table 2.

Summary of iTARGEX results from the association analysis for protein turnover rate and regulators of protein turnover. WPCC: Weighted Pearson's correlation coefficient; q-values are log-transformed; : the proportion of genes estimated to be significantly associated by the EM algorithm. Biological functions were taken from the Saccharomyces Genome Database (SGD) (39)

	iTARGEX
Regulators	WPCC	–log10(q-value)	π	Biological functions	Validation in this study
MRN1	0.225	35.444	0.921	Involved in translational regulation	v
UPF3	0.210	29.528	0.796	Involved in decay of mRNA decay pathway	v
PDE2	0.201	29.028	0.924	High-affinity cyclic AMP phosphodiesterase
YPR153W	0.191	25.323	0.896	ER chaperone for nutrient permeases
CAC2	0.182	24.203	0.907	Involved in DNA replication-dependent nucleosome assembly
SSN3	−0.179	22.991	0.904	Involved in protein destabilization	v
YDR306C	−0.177	21.054	0.947	Involved in ubiquitin-dependent protein catabolic process
MEI5	0.173	20.731	0.931	Involved in meiotic DNA recombinase assembly
SRB8	−0.172	20.668	0.908	Involved in regulation of transcription by RNA polymerase II
RAM1	−0.181	20.616	0.896	Involved in protein farnesylation	v
SSN8	−0.168	19.636	0.909	Involved in regulation of transcription by RNA polymerase II
ELP4	0.167	19.002	0.917	Required for Elongator structural integrity
ATG23	0.169	18.314	0.913	Involved in positive regulation of macroautophagy
AZF1	0.161	18.053	0.935	Involved in regulation of transcription by RNA polymerase II
CAF40	−0.166	17.581	0.886	Involved in positive regulation of transcription elongation
IRA2	0.160	16.808	0.815	Involved in negative regulation of Ras protein signal transduction
DDR48	0.159	16.471	0.945	Involved in DNA repair
UTP30	0.156	16.365	0.924	Involved in ribosomal small subunit biogenesis
SAM4	0.155	16.135	0.940	Cause abnormal vacuole, which is main site for protein turnover