FIGURE 1.

Global DNA methylation and hydroxymethylation profile in cervical cancer. (A) Average global methylation (left) and hydroxymethylation (right) levels of all CpG sites across the genome. (B) Absolute cytosine modification levels (C, mC, hmC) at individual CpG sites in each sample. (C) The ratio of 5hmC in 5mC modified sites and the ratio of 5mC in 5hmC modified sites. Abbreviations: CIN, cervical intraepithelial neoplasia; CC, cervical cancer; 5mC, 5‐methylation cytosine; 5hmC, 5‐hydroxymethylcytosine