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. 2021 Jul 19;11(7):e491. doi: 10.1002/ctm2.491

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© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Neoadjuvant treatment influence on immune cells and plasma factors. (A) Percentage of immune cells from peripheral blood and MFI on immune cells from peripheral blood. (B) Soluble factors secretion in plasma. (C) Cytokine secretion on plasma. Legend: Fold‐change (POST/PRE) from 0 to 2, 0 indicating (blue) a decrease after treatment, 1 (pink) indicates no changes, 2 (red) indicates increase, and >2 (dark red) indicates more than double of increase, and black squares (no data). Nonparametric Wilcoxon test was used for comparisons, (empty, not significant; *p‐value <.05; **p‐value <.01; ***p‐value <.001)