Table 4.
Retinal Vessel Caliber by Tertile of MPOD at Carotenoids in CAREDS Baseline Visits (2001–2004), in 390 Participants With Gradable Retinal Photographs From CAREDS2 Follow-up Visits (2016–2019)
| MPOD (ODU) CAREDS Baseline (2001–2004) | |||||
|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | β ± SE, P Value† | ||
| n | (0.00–0.29) | (0.29–0.48) | (0.48–1.00) | Tertile 3 vs. T1 | |
| Central retinal artery equivalents (µm) | |||||
| All participants | 390 | 141.4 ± 1.4 | 142 ± 1.4 | 144.4 ± 1.4 | 3.1 ± 2.0, P = 0.12 |
| MPOD stability over 15 years | |||||
| MPOD decrease* | 48 | 154.1 ± 7.7 | 143.5 ± 4.2 | 144.9 ± 3.2 | –9.2 ± 8.4, P = 0.28 |
| MPOD stable† | 106 | 135.8 ± 3.0 | 142.6 ± 2.6 | 149.8 ± 2.6 | 14.0 ± 4.1, P = 0.001 |
| MPOD increase‡ | 210 | 142.4 ± 1.7 | 142.5 ± 1.8 | 142.2 ± 2.1 | –0.2 ± 2.7, P = 0.95 |
| Central retinal venous equivalents (µm) | |||||
| All participants | 390 | 206.0 ± 2.1 | 211.6 ± 2.1 | 213.3 ± 2.1 | 7.3 ± 3.0, P = 0.02 |
| MPOD stability over 15 years | |||||
| MPOD decrease* | 48 | 218.4 ± 10.4 | 215.2 ± 5.6 | 209.0 ± 4.3 | –9.4 ± 11.3, P = 0.41 |
| MPOD stable† | 106 | 197.2 ± 4.1 | 210.2 ± 3.6 | 225.9 ± 3.6 | 28.8 ± 5.7, P < 0.001 |
| MPOD increase‡ | 210 | 207.8 ± 2.6 | 213.9 ± 2.9 | 207.8 ± 3.4 | 0.0 ± 4.3, P = 0.99 |
†
Ptrend adjusted for age, smoking pack-years (never smoker, <7, or ≥7 pack-years), self-reported hypertension, self-reported diabetes, total cholesterol, systolic blood pressure, and waist circumference.
MPOD decrease of >0.10 ODU, stable within 0.10 ODU or increase of >0.10 ODU between CAREDS baseline (2001–2004) and CAREDS2 (2016–2019).
Values are mean ± SE.