Table 2.
List of Top-Ranked Molecules
| Control vs. Acute NAION | |||||
|---|---|---|---|---|---|
| Protein | Delta | P | |||
| MCP1/CCL2 | −1.342 | 0.003 | |||
| MCP2/CCL8 | 1.383 | 0.0145 | |||
| SFAS/TNFRSF6 | 1.271 | 0.0205 | |||
| TPO | 1.132 | 0.021 | |||
| SICAM1 | 1.061 | 0.024 | |||
| EOTAXIN3/CCL26 | 1.216 | 0.0255 | |||
| TRAIL/TNFSF10 | 1.105 | 0.0275 | |||
| RESISTIN | 0.822 | 0.043 | |||
| Control vs. chronic NAION | |||||
| Protein | Estimate | Se | t | p | p. bonf. |
| IL1A | 1.41 | 0.37 | 3.8 | 0.0012 | 0.094 |
| IP10/CXCL10 | 1.16 | 0.3 | 3.8 | 0.0012 | 0.095 |
| SFAS/TNFRSF6 | 1.12 | 0.37 | 3 | 0.007 | 0.529 |
| TNFA | 1.24 | 0.41 | 3 | 0.008 | 0.609 |
| IL18 | 1.22 | 0.41 | 3 | 0.0084 | 0.64 |
| IFNG | 1.08 | 0.38 | 2.9 | 0.0101 | 0.771 |
| RESISTIN | 1.22 | 0.45 | 2.7 | 0.0134 | 1 |
| SVCAM1 | 1.15 | 0.42 | 2.7 | 0.0141 | 1 |
| PDGFAB/BB | −1.11 | 0.41 | −2.7 | 0.0144 | 1 |
| IL22 | 0.99 | 0.41 | 2.4 | 0.0256 | 1 |
| IL17A/CTLA8 | 1.03 | 0.44 | 2.3 | 0.0307 | 1 |
| PDGFAA | −0.94 | 0.4 | −2.3 | 0.0326 | 1 |
| IL12P40 | 0.86 | 0.38 | 2.3 | 0.0349 | 1 |
| TPO | 0.93 | 0.43 | 2.2 | 0.0433 | 1 |
| PAI1/SERPINE | 0.85 | 0.4 | 2.1 | 0.0491 | 1 |
In acute NAION, there were eight molecules that were distinct from age-matched controls (unadjusted P < 0.05, permutation test). In chronic NAION, there were 15 molecules that were distinct from controls (P < 0.05 for status effect in multiple linear regression. C-X-C motif chemokine ligand 10 (CXCL10) and interleukin-1α (IL-1α) had the smallest P values in Bonferroni test (top of the chronic list). Three proteins were common to acute and chronic NAION (italicized).
Delta, average over controls subtracted from the average over chronic cases; P, fraction of permutation tests that have delta at least as large as the observed delta; Estimate, linear regression coefficient; SE, standard error of the estimate; T, estimate/SE; p: P value of linear regression; p. bonf: P value of Bonferroni test.