Table 1.
Shows the effector cells, their respective acronyms, type of stimulation, the ICD construct in the lentiviral vector, and the arming BiAb.
| Term | Effector | Stimulation | Vector Transduced | Arming BiAb |
|---|---|---|---|---|
| Coactivated T cell (COATC) |
COATC | CD3/CD28 | None | Unarmed |
| HER2Bi Armed COATC | HER2 COATC | CD3/CD28 | None | HER2Bi |
| EGFRBi Armed COATC | EGFR COATC | CD3/CD28 | None | EGFRBi |
| Activated T cell (ATC) | ATC | anti-CD3 | None | Unarmed |
| HER2Bi Armed ATC | HER2 BATs | anti-CD3 | None | HER2Bi |
| EGFRBi Armed ATC | EGFR BATs | anti-CD3 | None | EGFRBi |
| Headless CAR T cells (hCART) |
hCART | CD3/CD28 | Yes | |
| hCART41BBζ | hCART | CD3/CD28 | 41BBζ | Unarmed |
| HER2 hCART41BBζ | HER2Bi | |||
| EGFR hCART41BBζ | EGFRBi | |||
| hCARTICOSζ | hCART | CD3/CD28 | ICOSζ | Unarmed |
| HER2 hCARTICOSζ | HER2Bi | |||
| EGFR hCARTICOSζ | EGFRBi | |||
| hCARTICOS-27ζ | hCART | CD3/CD28 | ICOS-27ζ | Unarmed |
| HER2 hCARTICOS-27ζ | HER2Bi | |||
| EGFR hCARTICOS-27ζ | EGFRBi | |||
| hCARTGFP | hCART | CD3/CD28 | GFP | Unarmed |
| HER2 hCARTGFP | HER2Bi | |||
| EGFR hCARTGFP | EGFRBi | |||
| hCARTCD28ζ | hCART | CD3/CD28 | CD28ζ | |
| hCARTζ | hCART | CD3/CD28 | ζ |